View Glossary

Histone acetylation status is determined by the balance in the activity of histone acetyltransferase (HAT) and HDAC, which in turn mediates chromatin remodeling within the chromosome.^8,10 Disruption of normal HAT or HDAC activities has been found in many human cancers.^7,8 Acetylation of the lysine tails of histones by HAT can open the chromatin structure, causing certain genes to become more accessible.¹⁰ The open chromatin structure allows for DNA transcription, such as tumor suppressor gene transcription.

This site makes use of the latest version of the Macromedia Flash Player. Download the player now!

• Histone Deacetylase (HDAC)

• SITE MAP
• PRIVACY POLICY
• TERMS OF USE
• COPYRIGHT 1995-2007 MERCK & CO., INC.
• MERCK & CO., INC. (USA)