HDAC education resources and information at HDACinfo.com

Epigenetics and Cancer

Review the influence of epigenetics on gene transcription and cancer

Epigenetics and Cancer

Epigenetic Modification of Cancer Cells

Histone Acetylation and Gene Expression

Histone Deacetylase (HDAC)

Explore the epigenetic process of histone deacetylation and its effect on gene regulation

Histone Deacetylase (HDAC)

Chromatin Structure and Gene Expression

HDAC Regulates Gene Expression

Role of HDAC in Cancer

HDAC Hypothesized Mechanism of Action Quiz

Oncology Resources

Access educational materials and Web links on HDAC and other emerging oncology targets

Oncology Resources

Oncology Web Links

Clinical Trial Links

Medical Society Links

References

Glossary of Selected Terms

View Glossary

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HDAC

Control Over Gene Expression, Impact on Cancer

The dynamic pathophysiology of cancer involves changes that arise from genetic modifications to the gene itself or heritable epigenetic modifications in gene function.^1–3 Epigenetic processes modulate when genes are expressed or repressed, and at what level they are expressed or repressed, without changes in the DNA sequence.^4,5 This site provides an introduction to epigenetics and cancer and the role of the enzyme histone deacetylase (HDAC) in aberrant gene expression. Links to other educational oncology resources are also available.